Introducing: theSIZE™

Next-Generation, Non-Hormonal Anabolic Amplification for the Here and Now

You've probably found yourself pleasantly shocked that a precision blend of specially selected actives could exert a genuine effect on a critical part of the muscle-building process. The very same process generally considered manipulatable only with drugs—namely, the actual partitioning and redirecting of nutrients to favor lean muscle growth at the expense of fat cell (adipocyte) growth. Indeed, in account after account and log after log, experienced lifters were reporting the same things: improved strength, better workouts, a greater overall sense of well-being, and—of course—accelerated gains. Moreover, these weren’t just ‘fill out’ gains—with chub and pump swelling in tandem. No, these were lean, dry, definition-enhancing gains.

theSIZE™, Avant Research’s custom-formulation protein-synthesis accelerator, is a product tailor-made to cement faster lean mass gains during bulks, and keep them fixed on your frame while dieting. With a precise blend of both fast and slow metabolizing creatines (creatine ethyl-ester and creatine monohydrate)-- among other powerful natural anabolic ingredients -- we guarantee you’ll be hard-pressed to find a superior all-in-one ergogenic cocktail. Those who've tried theSIZE™ agree that no natural product even comes close to rivaling it's anabolic and nutrient-partitioning potency.

theSIZE™ is formulated and designed to creates heightened anabolic efficiency in a ready-to-dose form. From increasing the anabolic impact of your meals for greater protein synthesis and, ultimately, greater muscle growth, to providing the optimal mix of pH buffering, cell-swelling, and fed-state signaling/tissue-turnover stimulating nutrients to instantly prompt anabolism, decrease catabolism, and induce swollen muscle pumps in and around workouts. theSIZE does it all, delivering carefully calculated amounts of specific micro- and macronutrients to lean tissues for total muscle-spawning synergy.

The Science of theSIZE: A Look at the Specs

Sparking theSIZE’s cellular tour-de-force of the body’s protein synthesis machinery is a three-pronged precision charge of ‘primers’, osmoregulators, and nutrient amplifiers.

Anabolic Primer Blend

First and foremost, theSIZE buffers for optimal homeostatic pH levels, itself an integral component to maintaining conditions ideal for cellular anabolism in skeletal muscle (1). Additionally, theSIZE donates a host of disparate ATP precursors—enabling us to induce a potent “fed state” (energy surplus) in the cell. This quasi-fed state prompts the muscle cell to increase protein synthesis during transient caloric influx (2,3) which positively shifts nitrogen balance and allows muscle mass to accumulate in the absence of unwanted overfeeding. Specific forms of the super minerals: calcium, magnesium, and zinc, are also united with the unparalleled oxidative stress eradicator N-acetyl-cysteine (NAC) to further optimize the protein-synthesis spectrum and guard against free-radical disruption of the body’s principal anabolic processes (4,5,6). Finally, the patented enzyme complex Aminogen™ frees a greater yield of dietary amino acids for your muscles to use for genuine tissue growth (7).

Osmo-anabolic Matrix

Coupled with these anabolic primers is theSIZE’s potent Osmo-anabolic Matrix. Osmolytes, as most are already aware, increase cell-volume in a fashion similar to the effects of insulin observed during periods of caloric surplus, but—and this is key—WITHOUT the equivalent calories & glucose-influx normally required. In the mass-building dynamic, cell-swelling and cell-size are paramount when it comes to diverting more metabolic energy to your muscles and promoting genuine myrofibrillar growth. After all, increased cell-volume not only promotes an increase in insulin signaling (8) and cell growth and proliferation (9), but it also elevates leptin expression and protein synthesis in muscle (10).

Anabolic Amplification Blend

Capping off the theSIZE formula is our pinpoint blend of anabolic nutrient signalers. These special “amplifier nutrients”: l-leucine, inositol hexaphosphate, and phytic acid work in tandem with the rest of the theSIZE to activate and increase transcription in key signal transduction pathways for anabolic hormones such as insulin (11) and IGF-1 (12), making their action in muscle increasingly potent. These same amplifiers also accelerate the productivity of the key protein synthetic pathway mTor (13) and promote satellite cell proliferation (14) in order to ultimately boost the most essential and powerful components of the cells muscle-building apparatus.

For a true anabolic boost that benefits the body, requires no cycling, stacks with any supplement for any situation, choose SytheSIZE. This is the new non-hormonal protein synthesis primer brought to you by the minds at Avant Research that will give new meaning to “maximizing your performance” and unsurpassed natural gains.

References

1. Kelger G et al. Acute metabolic acidosis decreases muscle protein synthesis but not albumin synthesis in humans. Am J Kidney Dis. 2001 Dec;38(6):1199-207.

2. Bylund-Fellenius AC et al. Protein synthesis versus energy state in contracting muscles of perfused rat hindlimb. Am J Physiol. 1984 Apr;246(4 Pt 1):E297-305.

3. Carling D. AMP-activated protein kinase: balancing the scales. Biochimie. 2005 Jan;87(1):87-91. Review.

4. Clausen T et al. Micronutrients, minerals and growth control. Bibl Nutr Dieta. 1998;(54):84-92. Review.

5. Cameron I et al. Cellular concentration of magnesium and other ions in relation to protein synthesis, cell proliferation and cancer. Magnesium. 1989;8(1):31-44. Review.

6. Patel J et al. Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem. 2002 Jun;269(12):3076-85.

7. MOLECULAR WEIGHT DISTRIBUTION OF WHEY, SOY AND CASEIN PROTEINS: A COMPARISON OF PROTEIN CONCENTRATE VERSUS HYDROLYZED PROTEIN VERSUS AMINOGEN DIGESTED(AMINOGENIZED™) PROTEIN; available at: http://www.triarco.com/images/studies/ms01.pdf

8. Schliess F et al. Cell hydration and insulin signalling. Cell Physiol Biochem. 2000;10(5-6):403-8.

9. Kim R et al. Impact of cell swelling on proliferative signal transduction in the liver.
J Cell Biochem. 2001 Jun 26-Jul 25;83(1):56-69. Review.

10. Grant A et al. Regulation of protein synthesis in lactating rat mammary tissue by cell volume. Biochim Biophys Acta. 2000 Jun 1;1475(1):39-46.

11. Combettes-Souverain M et al. Molecular basis of insulin action. Diabetes Metab. 1998 Dec;24(6):477-89. Review.

12. Singleton J et al. Insulin-like growth factor-I in muscle metabolism and myotherapies.
Neurobiol Dis. 2001 Aug;8(4):541-54. Review.

13. Proud C et al. Interplay between insulin and nutrients in the regulation of translation factors. Biochem Soc Trans. 2001 Aug;29(Pt 4):541-7. Review.

14. Molgo J et al. IP3 receptors and Ca2+ signals in adult skeletal muscle satellite cells in situ. Biol Res. 2004;37(4):635-9. Review.

Back to the research page